Correlation between rheumatoid arthritis and periodontitis

Introduction and aim. The association between periodontitis (PD) rheumatoid arthritis (RA) has been analyzed described in literature. Periodontal pathogens, such as “Porphyromonas gingivalis” “Aggregatibacter actinomycetemcomitans” are pointed the common factors for both diseases. In this work we demonstrate that treatment of dental oral diseases is an unconditional requirement patients with RA. Material methods. PubMed was searched keyword “rheumatoid arthritis” “periodontitis” from May 1999 to January 2022, showed 181 articles. Ultimately 72 articles were included review. Analysis above mentioned pathogens exhibit multiple mechanisms disturb immune inflammatory responses human organism. Those lead periodontal disease may activate systematic reactions which turn intensification (RA). P. gingivalis ability expresses PAD enzyme (peptidylarginine deiminase) activates citrullization process. Moreover, bacterium produces gingipain cysteine proteinases, degrade immunological system. latter pathogen, A. actinomycetemcomitans, hypercitrullization neutrophils. Conclusion. Both influence response organism, through pro-inflammatory mediators arthritis, intensify clinical manifestations